The current investigation examined coping repertoires of individuals who experience panic. Ninety-three subjects were divided into those with panic (n = 60), regardless of diagnosis, and those without panic (n = 33). Based upon a 27-item coping questionnaire, panic subjects reported utilization of strategies that were significantly greater in number and in frequency of use. Reliability estimates on the questionnaire were adequate. The questionnaire was factor analyzed, revealing seven factors: activity-indirect symptom focus, activity-direct symptom focus, help seeking, focus change, active struggle, self-injurious, and distraction. Panic subjects utilized more help seeking and change of focus coping techniques as compared to subjects without panic. When coping factors were examined for differences in perceived effectiveness, a self-injurious factor was found to be significantly less effective in reducing catastrophic thoughts and symptoms. A significant group x factor interaction occurred for thought reduction with panic subjects reporting greater effectiveness from help seeking. Results are discussed in terms of a re-evaluation of skill-based treatment rationales for panic given that subjects report coping strategies prior to treatment.